The patent application was filed final year with the United States Patent and Trademark Office (USPTO) according to a statement by the university.
The invention is an ethanolic extract of fruits from the Ajwa date palm to treat nearby haemorrhage and oedema brought on by snakebites.
Commenting on the invention, Prof Jabri mentioned that it is the outcome of a lot more than ten years of analysis perform. “It relates to a novel therapy for snake envenomation. It is an successful therapy utilizing ethanolic extract of the fruit from the Ajwa date (Phoenix dactylifera L)
palm to treat nearby haemorrhage and oedema induced by snake bites.”
The significance of this invention is connected to the reality that there are a lot more than five.5mn snakebites annually across the globe, which generally outcomes in nearly 2mn envenoming resulting in a lot more than 95,000 deaths.
Envenoming by snakes such as Echis ocellatus
and Naja naja nigricollis
is accountable for a number of clinical complications of serious systemic and nearby pathology.
For instance, E. ocellatus
leads to inflammation (such as swelling, blistering and necrosis) and haemorrhages due to each metalloproteases and ecarin (an enzyme that activates prothrombin). Also, envenoming by Naja naja nigricollis
induced clinical complications distinct from that brought on by E. ocellatus
. These consist of nearby necrosis, haemorrhage, complement depletion, and respiratory arrest or paralysis.
Prof Jabri mentioned that even though a number of efforts have been produced for successful remedial and preventive strategies, there is at present no sufficient therapy for nearby haemorrhage, oedema and necrosis brought on by snake envenomation.
Intravenous administration of anti-venom, ready from antibodies (IgG) of venom-immunised horses or sheep, is an successful therapy for systemic envenoming. However, anti-venom is of restricted effectiveness against the effects of nearby haemorrhage and oedema that create swiftly right after a snakebite.
Research to create therapy for nearby haemorrhage, oedema and dermonecrosis is consequently of clinical priority and has focused on the application of all-natural or synthetic inhibitors of snake venom potent molecules.
“The rational of the current invention was, therefore, to search for an agent that fulfil the drawbacks associated with the current anti-venom. Luckily after a long period of investigations, the inventors came up with an adequate and a novel method that results in the treatment of local hemorrhage caused by snake venoms. This not only prevents death but also other clinical complications associated with snake envenomation. Hence, this invention may also be applicable against other venomous creatures e.g. scorpions, sea snakes, poisonous frogs, spiders as well as others. The end-users of this invention can be tourists, soldiers, among others, who may be at risk of being exposed to poisonous creatures,” Prof Jabri mentioned.
Information Source: Muscat Daily